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Lifestyle adjustments that support digestion include modest post-meal activity, upright posture after eating, sleep hygiene, and stress-reduction techniques that modulate gut-brain sensitivity

It is important to recognise that tiredness can arise from multiple factors, including the underlying condition being treated (type 2 diabetes itself), changes in eating patterns due to reduced appetite, gastrointestinal side effects affecting nutrition, or concurrent medications

Observations across different programs indicate that weight changes may follow improvements in metabolic measures

The application of autophagy-related molecules as therapeutic targets to counteract DOR is still in its early stages and warrants additional research to clarify both their therapeutic potential and associated risks

Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies