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It is produced exclusively through solid-phase peptide synthesis and appears as a white lyophilized powder in its research-grade form

Long-term plasticity parameters initialization We assigned the initial state of the synapse 0 ( t = 0) to the potentiated ( 0 = 1) or depressed ( 0 = 0) state at random, using the individual synapse release probability, U SE , prescribed in the circuit model 5 as the probability of being in the potentiated state

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In addition, since cysteine levels in the bone marrow where stress erythropoiesis occurs in SCD patients are unavailable, as a surrogate, we determined cystine levels in SCD mouse spleen, where stress erythropoiesis occurred