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It has been modified from the natural GLP-1 sequence to resist degradation by the enzyme DPP-4, which is why it lasts much longer in the body than natural GLP-1

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Tirzepatide and the Heart Tirzepatide goes a step further than semaglutide because it mimics GLP-1 and another gut hormone called GIP (glucose-dependent insulinotropic polypeptide)

Similarly, another study found that semaglutide treatment resulted in approximately a 39% decrease in calories consumed from high-fat, high-sugar items (Gibbons et al., 2021)

Secondary endpoints showed 32.8% of patients treated with 2.4 mg semaglutide achieved both resolution of steatohepatitis with improvements in liver fibrosis (as compared to 16.2% of patients on placebo)