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Although surgical treatment and chemoradiotherapy for glioma have made certain progress in current medicine, the median survival time of these patients after diagnosis is still only about 12 months, and the main reasons affecting prognosis are the difficulty of radical resection of glioma and the tolerance to radiotherapy and chemotherapy ( Increased lactate secretion, inhibition of mitochondrial intima complex activity, activation of AMPK/mTOR signaling pathway and induction of ferroptosis are considered to be the main mechanisms of metformins anticancer effects ( An animal experiment observed the changes of metformin concentration in different brain regions, cerebrospinal fluid, and plasma after single and multiple oral administration of metformin in rats ( As mentioned earlier, metformin inhibits tumor cell proliferation, but the mechanism of action leading to this effect has not been fully identified

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Figure 3 4.1.1 Role of iron metabolism in ischemic stroke Prior to the formal identification of ferroptosis, studies had already linked iron accumulation to neuronal damage in both clinical settings and animal models of cerebral ischemia (35, 36, 131)

35 In IBD, you could have ongoing inflammation, and glutathione can help reduce that inflammation

10.14814/phy2.15881 30 GaoS