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Abbreviations DM: Diabetes mellitus HF: Heart failure EF: Ejection fraction HFrEF: Heart failure with reduced ejection fraction HFpEF: Heart failure with preserved ejection fraction HFmrEF: Heart failure with mildly reduced ejection fraction HFnEF: Heart failure with normal ejection fraction SGLT2i: Sodium glucose cotransporter 2 inhibitors GLP-1 RA: Glucagon-like peptide-1 receptor agonists DPP4i: Dipeptidyl peptidase 4 inhibitors LV: Left ventricular ANP: Abnormal natriuretic peptide EAT: Epicardial adipose tissue AGE: Advanced glycation end LVEF: Left ventricular ejection fraction HHF: Heart failure hospitalization CVD: Cardiovascular death NT-proBNP: N-terminal B-type ANP CIMT: Carotid intima-media thickness TNF-: Tumor necrosis factor- AMPK: Adenosine monophosphate kinase NLRP3: NOD-like receptor 3 ROCK: Rho-associated protein kinase PPAR: Peroxisome proliferator activated receptors References Gregory GA, et al

Oxidation kinetics for roGFP2 WT -PfGrx fusion constructs The in vivo oxidation kinetics from fusion constructs between roGFP2 WT and a variety of glutaredoxins and mutants thereof were shown to correlate very well with the rate constants for the oxidative half-reaction from GSSCys assays in vitro, suggesting that the glutathionylation of the glutaredoxin and not the transfer of oxidation to the fused roGFP2 moiety was rate-limiting under the chosen conditions 15,34,35

Keywords: autoimmune diseases, DPP4 inhibitors, inflammatory disorders, MERS-CoV, diabetes mellitus, COVID-19 Introduction Dipeptidyl-peptidase 4 (DPP4), also known as CD26, is a significant enzyme belonging to the SC serine peptidase clan, specifically within its subfamily 9b

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Rapid dose escalation increases risk significantly