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Achieving sufficient and sustained drug concentrations specifically at the site of myocardial injury remains a major obstacle for systemically administered agents due to poor pharmacokinetics, rapid clearance, and lack of specific targeting to affected cells ( Significant patient heterogeneity in baseline oxidative stress levels, comorbidities, and genetic predispositions further complicates a one-size-fits-all approach, influencing individual responses to targeted therapies (Zou et al., 2024)
The peptide demonstrates efficacy even when healing is compromised by concurrent corticosteroid administration, a significant advantage given that corticosteroids are commonly prescribed anti-inflammatory medications that typically impair tissue repair
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9 th ed
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