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Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels

DNMT3b protects centromere integrity by restricting R-loop-mediated DNA damage

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Thus, Htt reduces Cu 2+ to Cu 1+ , and copper promotes its aggregation, mediated by histidine residues ( Figure 6 schematizes the pathways that lead to symptoms of Huntingtons disease as a consequence of misfolded mutant Htt

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