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However, a long-term exploratory RCT in 150 people with obesity found that differences in eating disorders psychopathology scores were not maintained at 52 weeks when liraglutide in combination with behavioral therapy was compared with behavioral therapy alone 215

Its introduction into clinical practice offers a new horizon for improving metabolic outcomes in patients, with a favorable impact on CV risk factors

Some studies suggest small benefits in selected groups, while others show little or no effect

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AGS and SiNPs partially compensate the decrease in the metabolic activity and seH + , but SiNPs present a maximum at 1%2% after which the dose becomes too high or other mechanisms compensate and the effect reverses