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The primary mechanism driving weight reduction occurs in the hypothalamus, where these medications enhance satiety signals and reduce appetite

5 , 209ra151 (2013)

Moving from insulin to GLP-1 A patient on basal insulin whose Type 2 diabetes is relatively well controlled might transition to a GLP-1 agonist if they are gaining excessive weight on insulin, want to simplify their regimen, have developed cardiovascular risk factors that would benefit from GLP-1 protection, or have adequate remaining beta cell function

It is plausible that hyperbilirubinemia and acute favism may be two separate entities mechanistically

Importantly, any observed effects appear to be indirect consequences of metabolic improvement rather than direct pharmacological actions on the adrenal glands or HPA axis