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Patients with contraindicationsincluding personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, or severe gastrointestinal diseaseshould not use GLP-1 medications
Until now, various clinical trials have demonstrated that GLP-1R agonists show favorable efficacy and tolerable safety in lowering blood glucose in patients with DM (1416)
These researchers pointed to cost, too, but they also hypothesized that patients were only looking for a quick fix when using glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as Novo Nordisks brand names Wegovy and Ozempic
369,370 Later, quantitative real-time PCR analysis demonstrated that the administration of exendin-4, a GLP-1RA, resulted in significant upregulation of thyroid calcitonin mRNA levels in wild-type mice
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