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When used in combination with intensive lifestyle modifications, the average weight loss with Contrave increased to more than 11% of their starting body weight, compared to 7% who took a placebo
Both medications contain semaglutide, but they are FDA-approved for different uses
Klausen et al 37 reported adverse effects related to GI symptoms, body weight loss, fatigue, and injection site reactions, and the incidence was higher in the exenatide group compared with the placebo group
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[PubMed: 38286487] [Free PMC Article] Gabe MBN, Fuhr R, Sinn A, et al
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