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For instance, hypoxia-induced immunosuppression could potentially be reversed through co-administration of immune checkpoint inhibitors (313), while radiotherapy, which is less effective in hypoxic regions, may regain potency when combined with agents that reoxygenate tumors or sensitize hypoxic cells (314)
P.DavenportA
In healthy cells, FOXO4 binds to p53
In rats exposed to a colon cancer-causing chemical, the peptide reduced the number and size of colon tumors, particularly when administered during or after carcinogen exposure
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