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Another factor that aids the process is a localized increase in pH facilitated by SNAC, which leads to better solubility of semaglutide, as well as protection against degradation by stomach peptidases that have little activity at a neutral pH

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Patients on both therapies often experience synergistic metabolic improvements: testosterone supports muscle preservation and strength during weight loss, while GLP-1 medications accelerate fat loss and improve cardiometabolic markers

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