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Every compound in this class, from semaglutide to tirzepatide to these newer agents, causes nausea, vomiting, and diarrhea to some degree
Gastrointestinal side effect timing Beyond nausea, GLP-1 agonists can cause constipation, diarrhea, bloating, and acid reflux
The most effective strategy is slow dose escalation with 4-week holds
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