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Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice
It is an antioxidant which neutralizes the effect of free radicals and reactive species in the body
GSH depletion increases the % of apoptotic cells
And we focus on that first, along with behavioral counseling
Additionally, PQ downregulates SLC7A11 and GPX4 expression and upregulates cyclooxygenase-2 expression, thereby promoting oxidative stress and ferroptotic cell death (50)
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