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This structural modification also reduces its binding affinity to IGF binding proteins, allowing it to remain bioactive in circulation significantly longer than endogenous IGF-1
This temporal data underpins the research design rationale for PEG-MGFs extended half-life: it must be present during the acute 024-hour MGF signalling window and maintained through the proliferative phase
See also [edit] References [edit] "Inorganic Cyanide as Protecting Group in the Stereospecific Reconstitution of Vitamin B 12 from an Artificial Green Secocorrinoid" (PDF)
PMID: 87 LiYChangL-HHuangW-QBaoH-WLiXChenX-Het al
10.1080/09513590.2018.1488958 Gynecol Endocrinol
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