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By 2016, a review of tamoxifen trials in bipolar disorder concluded that tamoxifen was effective in the short-term treatment of mania, with results similar to lithium or valproate, with about 50% response rate across all three drugs

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Again, the total contribution between spouses may not exceed the annual family limit, but in this situation, both spouses have the ability to compensate for any contribution shortfalls of the other, or to simply choose which spouse's HSA it makes sense to fund first