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Key Benefits Significantly lowers A1C in patients with type 2 diabetes Reduces the risk of hospitalization for heart failure Offers protective cardiovascular and kidney benefits Convenient once-daily oral tablet No hypoglycemia risk when used alone Side Effects Common side effects include: Increased urination Urinary tract infections Genital yeast infections Thirst Low blood pressure Serious or rare side effects: Diabetic ketoacidosis (even with normal blood sugar) Acute kidney injury Severe urinary tract infections Fourniers gangrene (rare but serious genital infection) Dehydration or volume depletion Warnings and Precautions Not recommended for patients with Type 1 diabetes due to ketoacidosis risk May increase urination caution in elderly patients or those on diuretics Monitor kidney function before and during treatment Not indicated during pregnancy or breastfeeding Use with caution in patients with a history of urinary tract infections or genital infections Alternative Medications (by Indication) Farxiga (dapagliflozin) Invokana (canagliflozin) Steglatro (ertugliflozin) Rybelsus (semaglutide oral) for type 2 diabetes Ozempic (semaglutide injection) for type 2 diabetes and CV protection Entresto (sacubitril/valsartan) for heart failure Medication FAQs (Patient-Oriented Answers) What is Jardiance used for

Some digestive medications may be adjusted to optimize semaglutide absorption

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Asthma is often comorbid with T2DM and obesity [253, 254]

Researchers found that the mean difference suggested a potential improvement in IIEF-5 scores, indicating an improvement in ED among men in the GLP-1 group (mean difference, 2.84), though it was not statistically significant (95% CI, 2.89 to 8.57)