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The latest piece from Jomayra Herrera explores ways to rearchitect patient health through 1) deprescription programs that safely wean patients off drugs
Sci Rep 4:5832 Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, Dominguez-Diez A et al (2001) Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
S., de Matos, A
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Key Characteristics Mechanism of Action Pharmacological Profile Direct Receptor Activation Binds to IGF-1 receptors on target tissues Stimulates glucose uptake and utilization Promotes protein synthesis and cellular proliferation Activates intracellular signaling pathways (PI3K/AKT) Anabolic Effects Promotes muscle hypertrophy and satellite cell activation Enhances collagen deposition and tissue repair Stimulates mitochondrial biogenesis Supports bone mineralization Anti-Catabolic Action Inhibits muscle breakdown (proteolysis) Reduces protein degradation during stress Maintains lean mass during caloric restriction Supports recovery from injury or illness Key Advantages Over Natural IGF-1 Clinical Pearls: Metabolic Modulation: IGF-1 LR3 enhances insulin sensitivity and nutrient partitioning, making it particularly valuable in metabolic syndrome and insulin resistance states
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