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Starting at an age of 24 months, C57BL/6 mice display several of the HFpEF pathologies, including LV hypertrophy, diastolic dysfunction ( 2.2.2 Accelerated senescence model (SAMP, H 2 FPEF score 2) The senescence accelerated prone (SAMP) strain was generated by selective inbreeding of AKR/J mice ( 2.2.3 Fischer 344 rats (H 2 FPEF score 3) The aged Fischer 344 rats develop pathophysiology of aging in various organs, including the heart (Walker et al., 2006) with evident pulmonary congestion and exercise intolerance at 25 months of age (Walker et al., 2006), thus limiting the use of Fischer 344 rats as an HFpEF model
Cell Mol Life Sci 65:18361841
Targeting each step of glutamine metabolism has shown promising results in cancer treatment, prompting the discovery of druggable targets and the development of anticancer drug candidates 3
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