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Some patients taking Rybelsus have reported weight loss, though it is not officially approved only for weight loss or obesity
As such, the association with efficacy may be the result of enhanced trafficking of the protein within the cell that ultimately modulates the cell surface abundance of the receptor, rather than the result of alterations in the receptor protein structure that may influence ligand affinity
Discrepancies were resolved through collegial discussions
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Serious complications are rare but can include pancreatitis or kidney issues, so regular monitoring is important
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