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Membranes, especially those with an abundance of negatively charged lipids, are able to catalyze hiAPP transformation into an -helical structure, especially in the presence of free copper, which then leads to membrane penetration and pore formation (Sitton et al., 2025)

363,364 Dietary modifications, such as adherence to a low-purine diet and avoidance of alcohol, particularly beer and spirits, sugar-sweetened beverages, heavy meals, and excessive intake of meat and seafood, have demonstrated efficacy in reducing uric acid levels by approximately 10-15%

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