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Several mechanisms are thought to contribute, and these should be understood as hypotheses based on the drug's pharmacology and observations from related incretin-based therapies: Reduced caloric intake: Retatrutide significantly suppresses appetite, often leading to a substantial reduction in food consumption

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Michael Whalen, the team analyzed data from a large global health database

Positive outcomes were also observed in studies investigating associations between GLP-1 RAs and prostate cancer (lower risk in meta-analyses), while breast cancer shows no effect