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When patients first volunteer feedback about an adverse event, this is the drug companys golden moment to capture all of the detail that they and regulators will need to properly assess and record a safety signal
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have recently constructed a bioactivated in vivo assembly (BIVA) peptide (BIVA-PK) to recognize and kill a specific pro-fibrotic macrophages subset (Fn1 + Spp1 + Arg1 + ) [120]
It damages their membranes and helps sickle hemoglobin stick together
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