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Its extended half-life of approximately 4.7 days is attributed to its structural design, discussed in the large molecule conjugation section of this paper

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The gut microbial metabolite trimethylamine-N-oxide is present in human cerebrospinal fluid

Among its extra-pancreatic effects, GLP-1 decreases gastric acid secretion directly by inhibition of parietal cells and indirectly by stimulation of somatostatin (SST) secretion by D cells 10,11,12