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Methods A systematic literature search was conducted on PubMed and Embase (Ovid) databases using the search terms GLP-1 and pain
Comparative Trials of Glucagon-Like Peptide-1 Inhibitors and ActRII Inhibitors Clinical trials comparing GLP-1 RAs like semaglutide and dual incretin agonists (GLP-1RA/GIP) like tirzepatide, alone or in combination with myostatin inhibitors (bimagrumab, trevogrumab, and garetosmab), demonstrate varying effects on weight loss, body composition, and physical function in obese populations , (Table 2)
8, 15, 16 Activation of the glial cells may also have noxious consequences on neurons, as they may cause mechanical damages and alterations of the microenviroment
On the other hand, the risks of HHF (HR 0.93, 95% CI 0.831.04 with GLP-1RAs and HR 0.69, 95% CI 0.610.79 with SGLT2is) and composite kidney outcomes excluding macroalbuminuria (HR 0.92, 95% CI 0.801.06 with GLP-1RAs and HR 0.55, 95% CI 0.480.64 with SGLT2is) significantly reduced with SGLT2is only
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