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[5] Sustained NO Production - L-citrulline creates a longer-lasting elevation of plasma arginine levels compared to direct L-arginine supplementation, providing extended NO production benefits

doi: 10.3389/fphys.2022.954948 Received 27 May 2022 Accepted 28 July 2022 Published 25 August 2022 Volume 13 - 2022 Edited by Robert Roghair, The University of Iowa, United States Reviewed by Jeffrey Segar, Medical College of Wisconsin, United States Michael Satterfield, Texas A&M University, United States Updates Copyright 2022 Stremming, White, Donthi, Batt, Hetrick, Chang, Wesolowski, Seefeldt, McCurdy, Rozance and Brown

Small molecules and hypoxia

Doxil , an FDA-approved PEGylated liposomal doxorubicin, increases cancer tumor targeting and reduces cardiotoxicity through enhanced permeability and retention (EPR)

Chondrocytes lacking IR grown in micromass culture demonstrated a reduction in Alcian Blue staining that persisted even when cells were cultured in the presence of 10 nmolL 1 insulin, which was partially restored by the treatment of IGF-1 (Figure 3c)