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7) supporting a 1:1 stoichiometry of carnitine-Na + symport, which is in agreement with our occluded structure and previous functional studies on OCTN2 6,22,23,43,44
32,33 Moreover, immune checkpoint upregulation (PD-1, CTLA-4, TIGIT, LAG-3) and suppressive signaling cascades such as PTEN lossPI3K/AKT hyperactivation exacerbate T-cell dysfunction and resistance to ICIs
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Dietary fibre undergoes bacterial fermentation to produce short-chain fatty acids that bind to L-cell receptors (FFAR2 and FFAR3), directly stimulating GLP-1 release
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