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Markmiller, S
Santoro, A
What Studies Have NOT Demonstrated in Humans Despite community claims, no controlled human trial has demonstrated: A specific body fat percentage reduction attributable to LR3 IGF-1 cycling A specific lean mass gain figure for the standard 10-day-on / 4-week-off pattern Cardiovascular safety endpoints across repeated cycles Long-term cancer-incidence data for cycled LR3 IGF-1 use Epidemiological data on chronically elevated endogenous IGF-1 has raised theoretical cancer concerns (Yoshida & Delafontaine, 2020), and that concern is one reason community protocols favor short, spaced cycles rather than continuous use
High GHRH-R Selectivity No GHS-R1a Cross-Reactivity Modified GRF (1-29) demonstrates high selectivity for GHRHR, with minimal cross-reactivity to other pituitary hormone receptors including the growth hormone secretagogue receptor (GHS-R1a) that mediates the effects of ghrelin and GHRPs such as Ipamorelin
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