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Reductions in body weight were progressive through the course of the study, with no plateau observed for weight loss at 13 weeks
doi: 10.1152/ajpendo.1995.269.2.E309 93 TakahashiSSaegusaJSendoSOkanoTAkashiKIrinoYet al
This approval was based on the SELECT trial, which demonstrated significant cardiovascular risk reduction in this population
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