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These brain circuits connect to regions that modulate cortisol release and the hypothalamic-pituitary-adrenal (HPA) axis
Vanni et al
Food and Drug Administration has approved bronchial thermoplasty for treatment of severe refractory asthma but a follow up of the Phase 4 trial study participants to determine long-term effects of the procedure is still pending (Gildea 2011)
This rarely changes dosing recommendations but can make side effects last a few extra days after stopping
Once these effects became clear, clinical trials expanded to test GLP-1 drugs for weight management in people without diabetes
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