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Subsequently, the D m values of the four drugs were evaluated according to the Chou-Talalay median-effect principle as follows: Where D represents the treated dose and D m denotes the dose required to produce the median-effect (e.g., 50% inhibition of ROS generation, corresponding to IC50), and m is the Hill-type coefficient, which signifies the shape of the dose-effect curve

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Finally, the findings of reviewed studies provide further support for the antioxidative effects of riboflavin, although human studies are still very scarce

Journal of Molecular Medicine, 95(3), 323333