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Free Cu2+ is toxic (Fenton reactions, hydroxyl radicals), but the GHK-Cu complex is stable, diffusible and delivers copper in a targeted manner to copper-dependent metalloenzymes: lysyl oxidase (collagen/elastin crosslinking), Cu/Zn superoxide dismutase (SOD1, antioxidant defence), tyrosinase (controlled melanogenesis), dopamine-beta-hydroxylase

Note: Brightening from a rinse-off product accumulates over months rather than weeks, so this is a slow, steady contribution to tone rather than a visible change by a fortnight in

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Properly stored at room temperature (1530C), it maintains sterility and composition

Prescription NAD+ therapy takes a different approachsupporting cellular energy production directly