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It is a growth hormone-releasing hormone analog , which means the mechanism starts with signalling upstream of growth hormone rather than working through GLP-1-style incretin pathways
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They are used to: Improve glycemic management in people with diabetes Support weight loss in individuals with overweight or obesity Reduce cardiovascular risk in certain patient populations Most recently, to treat moderate to severe obstructive sleep apnea These medications are typically prescribed at FDA-approved doses and titrated gradually to manage gastrointestinal side effects like nausea, diarrhea, and upset stomach
What to discuss : Patients with a family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) should avoid GLP-1 agonists
