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As symptoms improve, gradually reintroduce activities

Folate deficiency leads to the accumulation of homocysteine which is associated with an increased risk of cerebrovascular diseases, depression, and dementia, with a focus on vascular dementia and Alzheimers disease (, , )

The variant rs2267721 has been associated with reduced HSL activity and a blunted lipolytic response to epinephrine infusion in a small but well-characterized clinical study (N=38) conducted at the NIH Clinical Center

DEPDC5 haploinsufficiency drives increased mTORC1 signaling and abnormal morphology in human iPSC-derived cortical neurons