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164 The carnitine palmitoyl transferases (CPT), the rate-limiting enzymes in the FAO pathway, transport long-chain acyl-CoA from the cytosol to mitochondria

Sci Rep 6 , 29743 (2016)

MOTS-c, by contrast, works from the inside of the mitochondria outward, activating the same primordial energy-sensing cascade that millions of years of evolution have refined into the body's most fundamental metabolic regulator

This suggests that GHK likely exists predominantly as GHK-Cu under normal physiological conditions (Pickart, 2008)

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