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Any abnormalities in calcium handling, such as delayed release or reuptake, can impair muscle function and coordination, thereby affecting knee stability and increasing the risk of ACL injury

Although the human body can produce glutathione on its own, production can have difficulty keeping up in times of excess stress, immune challenges, unhealthy microbial environments, or during aging, as glutathione status can decline with the natural aging process

77 This same type of bidirectional relationship exists between obesity and depression, and may reflect common mechanisms such as systemic inflammation and microbiome imbalance

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