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Their mechanism involves binding to receptors located throughout the body, including in the pancreas, gastrointestinal tract, and brain regions involved in appetite regulation

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Medication adjustments may be considered in consultation with prescribing clinicians: Dose reduction : Lowering the Ozempic dose may reduce symptom severity whilst maintaining some glycaemic benefit Slower titration : Increasing the dose more gradually than standard protocols may improve tolerability Prokinetic agents : In the UK, medications such as metoclopramide are generally restricted to short-term use (maximum 5 days) due to neurological side effect risks

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