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Both reactions can be catalysed by protein disulphide isomerase (PDI) and possibly other oxidoreductases that share common domains with PDI (for a recent review, see Ellgaard & Ruddock, 2005)
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In summary, different GLP-1RAs improve skeletal muscle atrophy through multiple molecular mechanisms, involving multiple pathways such as insulin resistance regulation, inflammation suppression, and mitochondrial function improvement (see Table 1), providing a theoretical basis for the clinical treatment of sarcopenia with GLP-1RAs
10.3390/biomedicines13010018 24 De RosaS
Drugs like semaglutide and tirzepatide are reshaping the management of obesity and cardiometabolic disease, with millions of patients now using them for sustained weight loss and risk reduction
