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For weight loss users, this means: Appetite suppression weakens or disappears Cravings return sooner than expected Weekly weight loss slows or stalls You might increase food intake without realizing the medication is the variable that changed For diabetes management, this means: Blood glucose readings drift upward Post-meal spikes become more pronounced A1C levels may rise at your next check You might need medication adjustments that would not have been necessary with full-potency semaglutide If you have been tracking your results and notice a sudden plateau, checking your medication expiration date should be one of the first things you investigate

Other side effects, like nausea or diarrhea, are uncommon at standard doses (500-2000 mg)

Horvath, A

Improvements in acne may appear within 6-8 weeks, but hirsutism typically takes 3-6 months to show noticeable changes

The combined effect of these mechanisms results in significant weight loss without the muscle loss often associated with traditional calorie-restriction diets