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The most honest assessment is that it helps prevent deficiencies and supports overall health during GLP-1 therapy, but it will not dramatically accelerate weight loss, eliminate all side effects, or replace the need for a nutrient-dense diet

Luo J, Zhang Z, Sun H et al (2020) Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice

"If we can kind of, like, tease out what is the effect of weight loss versus what is the direct effect of these medications on the upper airway, that will be very interesting." The most common side effects of GLP-1 drugs, including tirzepatide, are nausea, vomiting, diarrhea and constipation