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Whats more, theyre not a magic bullet and there are precautions to take
Could significantly reduce injection burden vs weekly dosing
One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)
The IC 50 s are 0.5 nM, 0.4 nM, 10 nM, and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M, and HER2, respectively
47 (3) : E44-E54
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