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Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression
Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regarding glycaemic control and body weight reduction
Glucagon-like peptide-1 receptor agonists and sodiumglucose co-transporter-2 inhibitors as combination therapy for type 2 diabetes: a systematic review and meta-analysis
The most plausible rationale for the discrepancy between preclinical/epidemiological success and clinical failure lies in the fundamental distinction between prevention and treatment
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