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Level B : controlled trials / RCT publications with relevant predefined outcomes (few directly relevant vaginal endpoints identified in accessible primary sources during this review)
L-carnitine in cardiogenic shock therapy: pharmacodynamic aspects and clinical data
Clinical trials of the FDA-approved branded version (studied as Zepbound) reported 16-22.5% weight reduction over 72 weeks in the SURMOUNT-1 trial
A foundational phase 2 dose-finding study established that a mean weight loss of 24.2% occurred at 48 weeks when using the maximum concentration [3]
But if you do not have type-2 diabetes and are looking to try Semaglutide to help you lose weight, well have a better idea of long-term safety once the FDA reviews data for this new indication
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