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Half-Life and Clearance Estimated Half-Life in Plasma Human pharmacokinetic data are unavailable, so half-life estimates stem from animal models

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Importantly, Trp-CA production was linked to bacterial bile salt hydrolase/transferase activity in Bifidobacterium , supporting the concept that microbial enzymatic diversification of bile acids can generate functionally important host-signaling molecules rather than passive metabolic by-products ( Emerging oxidized and epimerized secondary bile acid derivatives also illustrate how subtle microbial tailoring redirects host signaling toward immune regulation

This may induce anesthesiologist-led efforts to delay elective cases until a sufficient washout period, ideally up to 14 days for major surgery