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doi:10.1016/S0753-3322(03)00043-X Ubiyvovk VM, Ananin VM, Malyshev AY, Kang HA, Sibirny AA (2011) Optimization of glutathione production in batch and fed-batch cultures by the wild-type and recombinant strains of the methylotrophic yeast Hansenula polymorpha DL-1

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This provides more space to accommodate the B-ring of bicalutamide, allowing the AR to maintain a similar fold as that seen in other agonist-bound structures and thus favoring the formation of an active state of AF2

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