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Semaglutide combined with cagrilintide (1.2 mg and 2.4 mg) resulted in significantly greater weight loss (15.7% and 17.1%, respectively) at week 20 compared to semaglutide combined with placebo (9.8%) [123]
Further investigations are needed to confirm this hypothesis
5.6.5 Follow-up duration and attrition Median follow-up is 12 weeks (range 452 weeks), whereas progression/regression of DN typically manifests over years
You can certainly make the case that the comparison group - insulin treatment - may put patients at higher cardiovascular risk because of the negative impact of elevated insulin levels
That is the main problem with very long KLOW cycles: the longer the cycle gets, the less research we have to guide it
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