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identified a metabolic protein named 1-acylglycerol-3-phosphate O-acyltransferase 4 (AGPAT4), which facilitates the conversion of LPA to PA
GLP-1s work through systemic signaling: brain appetite circuits, gut motility, pancreas, liver-facing metabolic changes, and for tirzepatide/retatrutide, additional incretin and glucagon-receptor effects
In mice, treatment with a probiotic strain of Bifidobacterium elevated plasma levels of this hormone [108]
Exosomes from M1 macrophages, when loaded with cisplatin, increased the cytotoxicity of the drug by 3.3 times in drug-resistant ovarian cancer cells (A2780/DDP) and by 1.4 times in drug-sensitive cells (A2780) compared to cisplatin alone
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