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10.7554/eLife.66097 48 KlykovO.GangwarS
Cross-trial comparisons are useful for a general sense of scale, not a head-to-head verdict, because the study designs and patient groups differ
When guided by medical professionals with regular monitoring, TRT is safe and effective
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Certain patient groups may face a higher risk of adverse effects or complications with retatrutide and should approach its use with particular caution, or may be advised to avoid it altogether pending further evidence
In agreement with the profound anti-inflammatory effects of GLP-1RAs, a recent study demonstrated a protective effect of these medications against the development of non-exudative AMD compared with other diabetes and lipid-lowering medications
