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We conclude that the GLP-1 analog treatment prevented the decline of CMR glc that signifies cognitive impairment, synaptic dysfunction, and disease evolution
Where semaglutide, a GLP-1-only agonist, produces roughly 15% body weight loss on average, tirzepatide pushes past 20%
This sits in line with the International Society of Sports Nutrition position that higher protein intakes are needed to maximize retention of lean body mass during a calorie deficit
The resulting decrease in antioxidant capacity and increased sorbitol accumulation cause osmotic damage to nerve cells, worsening neuropathy [181]
8.5 Geriatric Use In controlled clinical trials [see Clinical Studies (14)] a total of 77 (7%) of the 1102 TRESIBA-treated patients with type 1 diabetes were 65 years or older and 9 (1%) were 75 years or older
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